I see enough patients with #hives that I sometimes get frustrated with our current treatment options and it doesn’t help when patients have the wrong idea or views about how hives behave. Vicki Lawrence to the rescue! I applaud her commitment to the truth about “idiopathic hives” and encourage you to listen to her video below (then learn how to avoid frustration with your own hives).
I want to be an expert. Always have and always will, but now it’s a little easier than 30 years ago. In fact, all you need now to become an expert is a little fame, a published book or memoir, and Shazam! you’re an authority on any subject you want to write on. So where’s the beef on my book?
Well, that’s not exactly how an allergist becomes an expert. I won’t bore you with the details, but doctors are trained by experience in the clinic (office) and reading about the medical conditions you have to treat….over and over again. Eventually your training ends and what do you do then? No more residency programs, no more allergy fellowships, and no more mentors. I have found a valuable resource through the American Academy of Allergy, Asthma, and Immunology (AAAAI) entitled “Ask the Expert” (hey they get paid for content, not the title). Here’s an example of a conversation about hives. (click on the link at the end) Patients all hate hives and just from this discussion alone I propose the following take home messages:
1.Hives are caused by allergy only 20% of the time. We usually want an easy answer, but if that were the case you would never show up in the allergy office. It’s important to look for the underlying cause of the hives, but in up to 50% of cases, the hives are due to autoimmunity….more on that later.
2.Once hivesare identified, change your mindset to 6-12 months of treatment. Hives can resolve spontaneously, but it doesn’t happen quickly.
3.Hives that bruise should be evaluated ASAP….no exceptions.
4.The usual dose of antihistaminesprescribed by your doctor is usually for treating hay fever. The effective dose for treating hives may be 4 times as high; beware of feeling sleepy for several days, but that side effect will usually improve.
5.I try to avoid steroids because of long-term side effects, but sometimes steroids are necessary to get the itching under control. Limit your use and look for alternative medications. But I will warn you, it’s not always allergy!
Yes, you too, can become an expert with your health—you’ll spend a lot less time in the doctor’s office if you do!
“I’m allergic to everything!” Ah, you’re smiling. Is this really possible to be allergic to multiple drugs? Evidently this is true according to a recent study published in Ann Allergy Asthma Immunol 108 (2012) 88–93.
Multiple drug intolerance syndrome: prevalence, clinical characteristics, and management byEric Macy, MD and Ngoc J. Ho, PhD.
So what is this condition? Multiple drug intolerance syndrome (MDIS) is generally defined as intolerance to 3 or more unrelated medications. This can be antibiotics, ibuprofen, or high blood pressure medication. The problem with adverse drug reactions is that intolerances are typically recorded in the “allergy” field of the medical record. This makes doctors and patients alike worry about anaphylaxis with any accidental use. Relax….most adverse drug reactions are not going to result in a severe reaction without warning. The authors of this paper use the word “allergy” in quotes throughout this paper to remind us that most of the drug “allergy” reports in the medical record are not immunoglobulin (IgE)-mediated.
Now don’t misunderstand, a true IgE-mediated allergy requires sensitization, and every systemic exposure in a sensitized individual can potentially result in anaphylaxis and death. But this is not the type of reaction we’re dealing with in this study.
If you have Multiple Drug Intolerance Syndrome, what can you do?
Most individuals with a record of any drug “allergy” have only 1 implicated medication, and they simply avoid that drug or class of medication. Individuals with multiple drug “allergies” are a special case.
Antibiotic overuse probably accounts for a significant proportion of the antibiotic “allergy” reported. Not only should antibiotics be avoided to prevent resistance, but overuse of antibiotics contributes to MDIS.
Challenge testing has typically shown tolerance to most medications in patients with MDIS. Schiavino et al performed 1,808 challenges on 480 patients, 84.4% female, most ages 40 to 60, with histories of ADRs to at least 3 unrelated medications.
All of these patients were evaluated at a specialized drug allergy clinic in Rome between January 1, 2000 and December 31, 2005. Two hundred twenty-four (12.4%) positive challenges were seen. In virtually all patients, either the index medication was tolerated on rechallenge or an acceptable alternative was identified.
Multiple drug “allergy” is relatively uncommon in children, and most adverse drug reactions (ADRs) in children are associated with antibiotic use. Park et al provided demographic information on 97 children with 2 or more antibiotic “allergies” seen in a specialized drug allergy center in Canada. The accompanying editorial concluded that rare individuals may truly have allergic reactions to unrelated antibiotics, but it also might just be opportunity and bad luck.
One often may stop multiple medications safely in the elderly. This may be the most important way to reduce the incidence of MDIS. In the presence of a life-threatening condition that would benefit from a particular medication associated with a historical reaction, based on a careful history, one may possibly safely test or rechallenge most individuals with MDIS.
So is there anyone who should NOT be challenged with a drug they suspect is causing MDIS?
Individuals who have experienced drug-associated toxic epidermal necrolysis, Stevens-Johnson syndrome, blistering, desquamation. These reactions are usually MORE severe after the second exposure!
Here’s what this type of reaction looks like:
Severe hepatitis, nephritis, or hemolytic anemia should not be rechallenged. The risk of inducing severe reactions is just too great. Fortunately, these severe reactions are rare.
Angiotensin-converting enzyme inhibitor–associated angioedema can be lethal, and rechallenge is not recommended.
If I have MDIS, when would a challenge be appropriate?
Urticaria or angioedema associated with NSAID use outside of aspirin-exacerbated respiratory disease is often transient, and rechallenge often can be safely performed.
Individuals with aspirin-exacerbated respiratory disease can be challenged with aspirin and desensitized.
Appropriate skin testing or in vitro IgE measurements can be used to evaluate individuals with MDIS who experienced classic IgE-mediated reactions such as anaphylaxis, shortness of breath, or hives. If negative, they can be rechallenged under observation.
If positive, they can be desensitized for 1 therapeutic course.
Multiple drug intolerance syndrome subjects with most other mild ADRs such as macular papular rashes, fixed drug eruptions, nausea, vomiting, gastrointestinal upset, diarrhea, drug fevers, other mild symptoms, or unknown symptoms can generally be safely rechallenged.
In closing, what’s the bottom line for patients with multiple drug “allergies?”
Multiple drug intolerance syndrome may be considered partially an iatrogenic condition.
Multiple drug intolerance syndrome is most prevalent in elderly women with high overall health care and pharmaceutical utilization.
Multiple drug intolerance syndrome is associated with anxiety but not with life-threatening illnesses or IgE-mediated allergy.
Coordinated efforts to reduce poly-pharmacy may be helpful in reducing iatrogenic MDIS.
Drug hypersensitivity testing or drug challenges can be used safely to help manage many individuals with MDIS.
Call me with questions; I’d be happy to help you out!
It’s January and thank goodness no blizzard like last year in Oklahoma! But…can you be allergic to the cold? Every year, I evaluate 1 or 2 patients with “cold-induced” urticaria and today was that day. The following video is from Mayo clinic, but this condition can and does happen in Oklahoma.
Scratching the Surface on Skin Allergies–Sooo many patients have skin allergy that results in a trip to the allergy office. How do I know if it’s allergy or something else? Do I need a dermatologist? If you’re a physician, please feel free to use the patient information handout here. If you’re a patient, I’ve included a great video on urticaria or hives that you’ll want to check out.
What would cause red, bumpy, scaly, itchy, inflamed/blistered or swollen skin? Dry skin, sunburn or an insect bite may be the cause. Or, you may have a skin allergy. The most common skin allergies include eczema, hives/angioedema and contact dermatitis.
Hives and Angioedema
Hives are red, itchy, raised areas which may be triggered by food, latex or drug allergies. Hives can also result from non-allergic sources like rubbing of the skin, cold, heat, physical exertion or exercise, pressure and sunlight. Hives usually go away within a few days. Chronic hives can linger for months to years, and this is the most common reason for allergy evaluation! Unfortunately, most cases of chronic hives come from the INSIDE, not something you eat or get exposed to outdoors. Don’t believe me?….check out this 5 minute video from Dr Meadows explaining chronic hives in detail. (He is from Alabama and very active with the College of Allergy, Asthma, and Immunology)
Contact dermatitis is often more painful than itchy. It is characterized by an itchy, red, blistered reaction from poison ivy, nickel, perfumes, dyes, latex products or cosmetics. Some ingredients in medications can cause a reaction, most commonly neomycin, an ingredient in antibiotic creams. Patients will often confuse a skin allergy with contact dermatitis & both conditions are very different from each other.
Allergic contact dermatitis reactions can happen 24 to 48 hours after contact. Once a reaction starts, it takes 14 to 28 days to go away, even with treatment. Skin allergy may occur within 1 hour after exposure. Big difference in your history-taking skills.
Did you know?
• About 27% of children who have food allergies also have eczema or skin allergies.
• Contact dermatitis leads to approximately 5.7 million doctor visits each year.
• More than 3,700 substances have been identified as contact allergens.
An apple a day might keep the doctor away, but what is modern hospital medicine really like? Follow Dr. Benjamin Kirkland - a Doctor working in Australia - through the pinnacles and pitfalls of everyday hospital medicine!