Jane (fictitious name, of course because of HIPPA regulations) is now 56 years old and just last year was diagnosed with #asthma. She thought, “no big deal, there are plenty of inhalers for me to use so I don’t wheeze”. Little did she know that 2019 would put her in the hospital 3 times and multiple visits to the emergency room because of asthma. In fact, she even missed her grandson’s graduation from kindergarten because of her asthma. Now if that doesn’t motivate you, nothing will! Continue reading New medications for Asthma–are we at the end of the line?
As #Christmas time approaches, it’s clear that Americans want choice. When I ask patients what they would like for Christmas, “I don’t know” is usually not their answer. Children’s eyes filled with sparkles at Santa’s coming, parents’ smiling at me and thankful I haven’t ruined their stories about Santa dominate our discussions about the holidays. Of course, I’ll always review medications and made sure that #asthma won’t ruin a perfectly good Christmas.
As an allergist in Tulsa, the myths that surround asthma, food allergy, hives, hay fever abound and patients often come in to the office telling ME what they are allergic to or how to fix the problem. Let me give you some examples:
Flying home from San Francisco spending some time at the AAAAI (American Academy of Allergy, Asthma, and Immunology) was a powerful reminder of how thankful I am for the opportunity to practice allergy here in the Midwest. National meetings give you updates of new procedures, opportunities to meet colleagues, and just a general good time getting out of the routine. What’s new for allergy here in Tulsa is more use of #biologicals (for #asthma), more #food challenges/treatment, and more aggressive treatment of #hives. I’m excited to get started, so let’s go!
Excuse my ranting and raving about myths in #allergy, but it’s true our minds need to “get in gear” for what we believe. Does it really make sense and does information we believe come from reliable sources? Let’s try and debunk a few myths about allergy while it’s fresh in your mind.
- Once I start allergy shots, I’ll never have any problems. #Allergy immunotherapy or “allergy shots” are very helpful to relieve symptoms of #hay fever such as sneezing, runny nose and even wheezing, but they don’t cure everything. For instance, if you have sinusitis, don’t count on your shots to cure your symptoms–you have to treat the sinuses for relief. This may include antibiotics/prednisone for one month at a time, or even surgical intervention. This is the reason I will often obtain a CT scan of the sinuses before starting allergy shots–to make sure I’m not missing an infection or anatomical obstruction in the sinus cavities. You wouldn’t expect the patient below to improve with allergy shots because they have a concha bullosa on the left side causing obstruction of nasal airflow. Not a good remedy for allergy shots!
- Benadryl is the antihistamine of choice–pick an ER and you’re likely to find #benadryl used like candy. Medical conditions like #hives and unknown #allergic reactions should be treated with antihistamines, but benadryl, really? Better antihistamines are available OTC and include Zyrtec and Xyzal. They’re stronger, more potent and last up to 24 hours instead of 4-6 hours like cousin benadryl. Next time you get benadryl, substitute with a better antihistamine and see what happens. (I think you’ll be pleased).
- Nasal spray addiction–Here in America, we don’t like using #nasal sprays. Europe has no problem sticking lots of objects up their nose, but in this country, we’d rather take a pill than use the more effective nose sprays. Every single study that compares nasal sprays with antihistamines, finds that nasal sprays such as corticosteroids work much better for allergies than pills and sometimes even allergy shots. WORD of CAUTION: Nasal sprays such as Afrin or 4-way spray can be addictive and harmful to your health. I’m only comparing nasal sprays with antihistamines and #topical steroids which don’t have addictive potential.
- There has to be a cause to my hives—perhaps the most frustrating medical condition of all time is #hives. That pesky rash that can range from a few bumps to your body being covered from head to toe with incredible itch associated with difficulty breathing and swelling. Most patients come in to the office hoping to find a cause or trigger to avoid and thus cure the hives. Unfortunately, the cause for hives is never found in 70% of cases, only leading to more frustration and disgust. I will usually look for allergy, bone marrow problems (tryptase) and alpha gal sensitivity, but that’s about it for finding a cause. Symptom control is key with antihistamines and Xolair, but if you stop your medication, the hives are likely to return.
No, I’m not done with allergy myths, but part 2 is coming up later. Those topics to include the following:
- Can I get over asthma?
- Isn’t everyone allergic in Oklahoma? I’ve come to the right state;
- Food allergy–https://www.usatoday.com/videos/travel/experience/food-and-wine/2018/07/07/these-foods-can-help-you-feel-cool-heat/36661435/
If you don’t believe me, here’s an hour long lecture on “Allergy myths” given by Dr. Dave Stukus (teaches at Ohio State University) at the following link:
I see enough patients with #hives that I sometimes get frustrated with our current treatment options and it doesn’t help when patients have the wrong idea or views about how hives behave. Vicki Lawrence to the rescue! I applaud her commitment to the truth about “idiopathic hives” and encourage you to listen to her video below (then learn how to avoid frustration with your own hives).
A little information about how hives behave can go a long way in understanding how to treat them. Continue reading The Carol Burnett show–4 things to avoid frustration with your hives
I want to be an expert. Always have and always will, but now it’s a little easier than 30 years ago. In fact, all you need now to become an expert is a little fame, a published book or memoir, and Shazam! you’re an authority on any subject you want to write on. So where’s the beef on my book?
Well, that’s not exactly how an allergist becomes an expert. I won’t bore you with the details, but doctors are trained by experience in the clinic (office) and reading about the medical conditions you have to treat….over and over again. Eventually your training ends and what do you do then? No more residency programs, no more allergy fellowships, and no more mentors. I have found a valuable resource through the American Academy of Allergy, Asthma, and Immunology (AAAAI) entitled “Ask the Expert” (hey they get paid for content, not the title). Here’s an example of a conversation about hives. (click on the link at the end) Patients all hate hives and just from this discussion alone I propose the following take home messages:
1. Hives are caused by allergy only 20% of the time. We usually want an easy answer, but if that were the case you would never show up in the allergy office. It’s important to look for the underlying cause of the hives, but in up to 50% of cases, the hives are due to autoimmunity….more on that later.
2. Once hives are identified, change your mindset to 6-12 months of treatment. Hives can resolve spontaneously, but it doesn’t happen quickly.
3. Hives that bruise should be evaluated ASAP….no exceptions.
4. The usual dose of antihistamines prescribed by your doctor is usually for treating hay fever. The effective dose for treating hives may be 4 times as high; beware of feeling sleepy for several days, but that side effect will usually improve.
5. I try to avoid steroids because of long-term side effects, but sometimes steroids are necessary to get the itching under control. Limit your use and look for alternative medications. But I will warn you, it’s not always allergy!
Yes, you too, can become an expert with your health—you’ll spend a lot less time in the doctor’s office if you do!
“I’m allergic to everything!” Ah, you’re smiling. Is this really possible to be allergic to multiple drugs? Evidently this is true according to a recent study published in Ann Allergy Asthma Immunol 108 (2012) 88–93.
Multiple drug intolerance syndrome: prevalence, clinical characteristics, and management byEric Macy, MD and Ngoc J. Ho, PhD.
So what is this condition? Multiple drug intolerance syndrome (MDIS) is generally defined as intolerance to 3 or more unrelated medications. This can be antibiotics, ibuprofen, or high blood pressure medication. The problem with adverse drug reactions is that intolerances are typically recorded in the “allergy” field of the medical record. This makes doctors and patients alike worry about anaphylaxis with any accidental use. Relax….most adverse drug reactions are not going to result in a severe reaction without warning. The authors of this paper use the word “allergy” in quotes throughout this paper to remind us that most of the drug “allergy” reports in the medical record are not immunoglobulin (IgE)-mediated.
Now don’t misunderstand, a true IgE-mediated allergy requires sensitization, and every systemic exposure in a sensitized individual can potentially result in anaphylaxis and death. But this is not the type of reaction we’re dealing with in this study.
If you have Multiple Drug Intolerance Syndrome, what can you do?
Most individuals with a record of any drug “allergy” have only 1 implicated medication, and they simply avoid that drug or class of medication. Individuals with multiple drug “allergies” are a special case.
Antibiotic overuse probably accounts for a significant proportion of the antibiotic “allergy” reported. Not only should antibiotics be avoided to prevent resistance, but overuse of antibiotics contributes to MDIS.
Challenge testing has typically shown tolerance to most medications in patients with MDIS. Schiavino et al performed 1,808 challenges on 480 patients, 84.4% female, most ages 40 to 60, with histories of ADRs to at least 3 unrelated medications.
All of these patients were evaluated at a specialized drug allergy clinic in Rome between January 1, 2000 and December 31, 2005. Two hundred twenty-four (12.4%) positive challenges were seen. In virtually all patients, either the index medication was tolerated on rechallenge or an acceptable alternative was identified.
Multiple drug “allergy” is relatively uncommon in children, and most adverse drug reactions (ADRs) in children are associated with antibiotic use. Park et al provided demographic information on 97 children with 2 or more antibiotic “allergies” seen in a specialized drug allergy center in Canada. The accompanying editorial concluded that rare individuals may truly have allergic reactions to unrelated antibiotics, but it also might just be opportunity and bad luck.
One often may stop multiple medications safely in the elderly. This may be the most important way to reduce the incidence of MDIS. In the presence of a life-threatening condition that would benefit from a particular medication associated with a historical reaction, based on a careful history, one may possibly safely test or rechallenge most individuals with MDIS.
So is there anyone who should NOT be challenged with a drug they suspect is causing MDIS?
Individuals who have experienced drug-associated toxic epidermal necrolysis, Stevens-Johnson syndrome, blistering, desquamation. These reactions are usually MORE severe after the second exposure!
Here’s what this type of reaction looks like:
Severe hepatitis, nephritis, or hemolytic anemia should not be rechallenged. The risk of inducing severe reactions is just too great. Fortunately, these severe reactions are rare.
Angiotensin-converting enzyme inhibitor–associated angioedema can be lethal, and rechallenge is not recommended.
If I have MDIS, when would a challenge be appropriate?
- Urticaria or angioedema associated with NSAID use outside of aspirin-exacerbated respiratory disease is often transient, and rechallenge often can be safely performed.
- Individuals with aspirin-exacerbated respiratory disease can be challenged with aspirin and desensitized.
- Appropriate skin testing or in vitro IgE measurements can be used to evaluate individuals with MDIS who experienced classic IgE-mediated reactions such as anaphylaxis, shortness of breath, or hives. If negative, they can be rechallenged under observation.
- If positive, they can be desensitized for 1 therapeutic course.
- Multiple drug intolerance syndrome subjects with most other mild ADRs such as macular papular rashes, fixed drug eruptions, nausea, vomiting, gastrointestinal upset, diarrhea, drug fevers, other mild symptoms, or unknown symptoms can generally be safely rechallenged.
In closing, what’s the bottom line for patients with multiple drug “allergies?”
Multiple drug intolerance syndrome may be considered partially an iatrogenic condition.
Multiple drug intolerance syndrome is most prevalent in elderly women with high overall health care and pharmaceutical utilization.
Multiple drug intolerance syndrome is associated with anxiety but not with life-threatening illnesses or IgE-mediated allergy.
Coordinated efforts to reduce poly-pharmacy may be helpful in reducing iatrogenic MDIS.
Drug hypersensitivity testing or drug challenges can be used safely to help manage many individuals with MDIS.
Call me with questions; I’d be happy to help you out!
It’s January and thank goodness no blizzard like last year in Oklahoma! But…can you be allergic to the cold? Every year, I evaluate 1 or 2 patients with “cold-induced” urticaria and today was that day. The following video is from Mayo clinic, but this condition can and does happen in Oklahoma.
Here is a link to USAToday and the same condition–>Allergic to Cold!