New Biologicals are unknown

What is the magic bullet of medical treatment? How about a biological that treats two or more diseases at one time? Dupilumab (Dupixent) is one such medication and I agree with Dr. Castro’s interpretation of the data on dupilumab–after all, he wrote the study. Here’s what I like about Dupixent:

  1. Blocks 2 cytokines, both IL-4 and IL-13
  2. Treats 3 different diseases: asthma, nasal polyps, and atopic dermatitis.
  3. If you can’t get approved through your insurance, the company has a very good patient assistance program that makes Dupixent affordable for most patients.

Xolair, xolair, xolair. This biological has been around since my days back in Kansas. I have to admit, when Xolair was first released 20 years ago, I thought “who would use this type of medication?” Not only was I wrong, but Xolair has now set the standard for the use of monoclonal treatment of allergic disease, asthma, and urticaria. But I can’t compete with the video on Xolair….enjoy!

The last biological I mention is one that wasn’t the first on the scene, but has made it’s impression with a unique mechanism for getting rid of allergic inflammation: why not block the eosinophil IL-5 receptor directly? What do I like about Fasenra?

  1. Gets rid of eosinophils quickly–you notice within several weeks many times when Fasenra makes you feel better.
  2. After the first 3 doses, you only have to use Fasenra every OTHER month–pretty cool schedule compared to a daily inhaler.
  3. Reduces both exacerbations of asthma AND the need for corticosteroids.